SMART CAMP: Critical Analytics for Manufacturing Personalised-Medicine
SCIENTIFIC ADVISORY COMMITTEE MEETING
12-13 JAN 2023
Venue: CREATE Theatrette, Level 2 CREATE Tower
CAMP Scientific Advisory Committee (SAC) MEMBERS:
• Prof. Viola Vogel, ETH-Zurich (Chair)
• Dr. Nina Bauer, Millipore Sigma
• Prof. Dario Campana, National University of Singapore
• Dr. Ken LeClair, Lykan Bioscience
• Dr. Antonio Lee, Medipost
• Dr. Travis McCready, Jones Lang Lasalle (JLL)
Day 1 (Thursday, 12 Jan 2023)
8:00 – 8:30 am: Registration
8:30 – 9:15 am: Welcome and CAMP Overview
- Welcome:CAMP Co-Leads, Profs. Krystyn Van Vliet and Hanry Yu
- Opening remarks by SMART CEO (Prof. Gene Fitzgerald)
- CAMPOverview, including SAB 2022 response: Profs. Krystyn Van Vliet and Hanry Yu
- SAC Agenda Overview:CAMP Scientific Director, Dr. Yie Hou Lee
9:15 – 10:15 am: Cross Cut A - Mesenchymal stromal cell therapy for cartilage repair
- Aims and Year 4 goals in review: Drs. Zhiyong Poon and Yang Zheng (Crosscut A Co-Captains)
- CQA vignette: Dr. Ekta Makhija, “Self-organized patterns in mesenchymal stromal cell populations predict in vitro chondrogenesis”
- PAT vignette: Dr. Ching Ann Tee, “Metabolic modulation of MSC phenotypic commitment”
10:45 – 11:45 am: Cross Cut B - CAR-T cell therapy for acute myeloid leukemia
- Aims and Year 4 goals in review: Prof. Michael Birnbaum (Crosscut B Captain)
- PAT vignette: Dr. Wei Xiang Sin, “Perfusion-based micro-bioreactors for production of CAR T cell therapies”
- Rapid safety analytics vignette: Dr. James Strutt, "Extracting sources of sequencing variance in low biomass samples"
1:00 - 2:00 pm: Rapid safety CQAs
- Aims and Year 4 goals in review: Dr. Stacy Springs and Prof. Rohan Williams (Flagship 2 Co-Captains)
- Translation vignette: Dr. Xiaolin Wu, “Rapid safety CQAs tests using CRISPR/Cas and isothermal reaction”
- CQA vignette: Dr. Cheryl Choo, “Spent media-derived extracellular viral RNA as identifiers of virus infection in cell suspensions”
2:00 – 2:50 pm: Rapid Fire Presentations (90 sec overviews each posters)
2:50 – 4:30 pm: CAMP Poster Presentations
4:30 – 5:30 pm: CAMP Lab Demonstrations
- Microbioreactors in action (Dr. Wei Xiang Sin et al.)
- MRR (Dr. Daniel Roxby + Kaiser et al.)
- Microfluidic differential lateral displacement cell analysis systems (Dr. Kerwin Kwek + Chin Ren + Kai Yun)
Day 2 (Friday, 13 Jan 2023)
9:00 – 9.05 am: Welcome and CAMP1.0 Transitions: Profs. Krystyn Van Vliet and Hanry Hu
9:05 – 10:05 am: CAMP seed projects and IntraCREATE updates
- CAMP seed project: "Optimizing MSC phenotype for immunomodulation via controlling culture confluency" by Shu Hui
- IntraCREATE-1: "Managing undifferentiated cells from iPSC-derived regenerative medicine" by Dr. Daniel Roxby
- IntraCREATE-2: Retinal Analytics via Machine learning by George Barbastathis
10:30 am - 12:00 pm: CAMP2.0 update and overview: Profs. Jongyoon Han & Michael Birnbaum
